Screening of Functional Norepinephrine Transporter Insensitive to Cocaine Inhibition and Generation of Knock-in Mouse Dissertation
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چکیده
............................................................................................ii Acknowledgments................................................................................vi Vita...................................................................................................vii List of Tables......................................................................................xii List of Figures.....................................................................................xiii List of Abbreviations..............................................................................xv Chapters
منابع مشابه
Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter.
There are three known high-affinity targets for cocaine: the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET). Decades of studies support the dopamine (DA) hypothesis that the blockade of DAT and the subsequent increase in extracellular DA primarily mediate cocaine reward and reinforcement. Contrary to expectations, DAT knockout (DAT-KO) mic...
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Selective blockers of the norepinephrine transporter (NET) inhibit dopamine uptake in the prefrontal cortex. This suggests that dopamine in this region is normally cleared by the somewhat promiscuous NET. We have tested this hypothesis by comparing the effects of inhibitors selective for the three monoamine transporters with those of a nonspecific inhibitor, cocaine, on uptake of 3H-dopamine in...
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The inhibition by cocaine of inward and outward transport of dopamine (DA) at the cloned human norepinephrine transporter (hNET) and the relationship of the inhibitory patterns of cocaine to the conformational requirements of the transporter were investigated. This was done using rotating disk electrode voltammetry in transfected cells. The uphill uptake of external DA, the lack of inhibition b...
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